Luminal disease and perianal fistulas get different plans
Stem cell therapy for Crohn's disease in Istanbul, Turkey
Our Istanbul team matches your exact Crohn's phenotype — luminal, stricturing, or perianal fistula — to the right standard care and cell research context.
Condition-specific editorial anatomy. Explanatory labels remain in accessible text.
Direct answer
What the current evidence says
We don't offer a one-size-fits-all cell infusion for Crohn's disease, because the most developed cell research used a specific product placed locally around complex perianal fistulas after surgery — not an IV treatment for luminal disease. We're upfront that Alofisel, the leading product in this space, was withdrawn from the EU market after a confirmatory trial did not beat placebo. Our program is built around your exact phenotype, keeping your biologics and surgical care in place. Request your free medical evaluation to see what applies to you.
Clinical map
Start with the diagnosis, stage, and treatment context
We always separate luminal inflammation, strictures, abscesses, and perianal fistulas, and name the exact product and route under discussion.
Established care comes first
- Treat-to-target medical care: We help you access guideline-selected biologic or small-molecule therapy with objective monitoring.
- Surgical partnership: We coordinate abscess drainage, stricture and fistula management, and seton and medication timing with your surgical team.
- Whole-patient support: Nutrition, anemia, bone health, infection risk, and mental health are all part of your plan.
- 01
Luminal inflammatory disease
Endoscopic activity, symptoms, calprotectin, CRP, and imaging guide your anti-inflammatory care.
- 02
Stricturing or penetrating disease
Obstruction, abscess, and nutritional compromise can require urgent imaging and surgery, which we coordinate promptly.
- 03
Perianal fistulizing disease
Pelvic MRI, drainage, setons, and colorectal expertise define your pathway here.
Evidence position
What is known, what is investigational, and what is not demonstrated
Phenotype-specific, physician-led planning
Biologics, small molecules, nutrition strategies, and surgery remain the backbone of your care, matched to your diagnosis and phenotype.
Perifistular is a local surgical protocol
An active abscess or uncontrolled sepsis gets drainage and conventional care first, always, before any elective procedure.
We never let sepsis care wait
Results vary between patients and stem cell therapy is not a guaranteed cure — we won't market local fistula evidence as an IV cure.
Product and route
A mechanism is not a clinical outcome
- 01
Perifistular is a local surgical protocol
The studied pathway included tract preparation and infection control — we explain that it's not interchangeable with IV or intrathecal delivery.
BoundaryEvidence applies only to the studied product, population, dose, route, comparator, and endpoint.
- 02
We never let sepsis care wait
Fever, escalating perianal pain, or systemic illness gets urgent gastroenterology and surgical assessment before anything else.
BoundaryEvidence applies only to the studied product, population, dose, route, comparator, and endpoint.
Evidence ledger
Read the actual study, including the result that did not change
Each row keeps product identity, route, endpoint, and limitation together so one trial cannot become a generic treatment claim.
01 Darvadstrocel for complex perianal fistulas
Open source- Product
- Expanded allogeneic adipose-derived MSCs
- Route
- Local injection around surgically prepared fistula tracts
- Design
- Randomized confirmatory phase 3 trial after earlier pivotal research
- Finding
- The confirmatory ADMIRE-CD II study did not show a statistically significant difference from placebo for combined remission.
- Limitation
- This product-specific result does not address luminal Crohn's disease or support another cell source, route, or exosome product.
Outcomes before travel
Decide what meaningful change would look like
A baseline and a time point matter more than an isolated testimonial. These measures should be chosen before any intervention.
- 01
Endoscopic response or remission
- 02
Fecal calprotectin and CRP
- 03
Fistula drainage and pelvic MRI healing
- 04
Steroid-free remission and treatment persistence
- 05
Hospitalization, surgery, abscess, and continence outcomes
Specialist review
What a complete Istanbul review needs
Our Istanbul team matches your exact Crohn's phenotype — luminal, stricturing, or perianal fistula — to the right standard care and cell research context.
Records and baseline
- Confirmed Crohn's phenotype, location, behavior, and disease duration
- Recent colonoscopy, pathology, calprotectin, CRP, and imaging
- Pelvic MRI, fistula map, seton, and abscess history when relevant
- Current and previous biologics, small molecules, and surgery
- The exact cell product, technique, and follow-up we recommend for you
Safety and planning checks
- We never ask you to interrupt effective Crohn's therapy or remove a seton without your treating team's guidance.
- Active abscess, obstruction, or severe flare gets stabilized before travel.
- Your Istanbul plan clearly states whether the goal is luminal inflammation or one mapped perianal fistula outcome.
Transparent planning
Build the medical plan before the package
A quote should follow record review, product disclosure, route rationale, and a written follow-up plan. This page does not invent a universal price.
- We never ask you to interrupt effective Crohn's therapy or remove a seton without your treating team's guidance.
- Active abscess, obstruction, or severe flare gets stabilized before travel.
- Your Istanbul plan clearly states whether the goal is luminal inflammation or one mapped perianal fistula outcome.
Questions the plan must answer
- 01
Perifistular is a local surgical protocol: The studied pathway included tract preparation and infection control — we explain that it's not interchangeable with IV or intrathecal delivery.
- 02
We never let sepsis care wait: Fever, escalating perianal pain, or systemic illness gets urgent gastroenterology and surgical assessment before anything else.
Primary reading
Guidelines, trials, and regulatory context
FAQ
Questions patients ask before an Istanbul review
Request Medical Evaluation
Begin a personalized treatment conversation with our medical team.
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